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Fourman et al

There is very little evidence that vitamin B-12 injections or supplements will directly lead to weight loss

Multiple trials have robustly shown a strong association of NNMT with IR and T2D (Kraus et al., 2014

doi:10.21037/tau.2018.06.20

And the thing thats important here is it is ceruloplasmin, which is a copper containing protein made in the liver that converts the storage iron into the active form

A few commenters recommended pilot testing in diverse settings and populations to ensure reliability, practicality, and applicability of new measures before full implementation