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Despite the availability of limited pharmacological treatments, current approaches primarily focus on symptom management rather than modifying disease progression

In bipolar disorder, the number of GFAP-positive astrocytic profiles decreases, accompanied by astrocytic atrophy 271,293,294

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Instrumental variables (IVs) used in the MR analysis were selected based on three key assumptions [30]: (1) Relevance assumption: IVs must be strongly associated with carnitine