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A VD model is established in rats by permanent common carotid arteries (CCA) ligation, caused cerebral ischemia, reduced blood flow, cognitive impairment, and neuronal damage [27] Daily oral HupA (0.1 mg/kg) for 14 days restored hippocampal choline acetyltransferase activity and normalized superoxide dismutase (SOD), lipid peroxide, lactate, and glucose levels [49]

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The expression of NMR-1 using the heterologous glr-1 promoter helped us to exclude the possible involvement of the germline in this GSSG-mediated learned aversion because the glr-1 gene is expressed in most NMR-1-expressing interneurons, such AVA, AVD, and AVE neurons 61 , though not in the germline