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464 LPA also promotes IL-8 secretion and upregulates MDR1, Bcl2 (B-cell lymphoma 2), Bcl-xl (B-cell lymphoma extralarge), and XIAP (X-linked inhibitor of apoptosis protein), enhancing chemoresistance via the PI3KAkt and RasMEKERK pathways

When systemic glutathione levels are low, the resulting unchecked oxidative stress acts as a constant irritant to mast cells, keeping them in a hyper-reactive state