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Air pollutants potentially affect MTHFR gene expression through genotoxicity and epigenetic modifications, leading to changes in DNA methylation patterns

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This finding is supported by that of another study 36 , which reported the association of ER stress with autophagy and cardiomyocyte remodeling in experimental and human atrial fibrillation

364 In an APP/PS1 mouse model of AD that carries human AD-linked mutations in APP and PSEN 1 genes, UA restored neuronal mitophagy, ameliorated cognitive decline, reduced A pathology, and mitigated neuroinflammation