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It is metabolized primarily in the liver and other tissues by COMT

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doi: 10.1038/s41577-022-00816-y 7 MiguelVShawIWKramannR

Diverse delivery systems for dietary polyphenol encapsulation Although it was mentioned in the previous chapter that polyphenols exhibit significant anti-inflammatory and antioxidant properties, their further development is constrained by issues such as instability, limited bioavailability, and low biological activity

It is crucial to identify the core targets that lead to pathological changes from quantitative to qualitative changes during this process, and the above preventive interventions, sleep improvement, physical exercise, dietary regulation, and social intervention, may prolong or reverse the subclinical pathological stage (Fig