melanotic in situ Labial macule. B). Increased numbers of me-lanocytes along Acral lentiginous melanoma in situ:

doi: 10.3389/fphar.2026.1762214 Received 06 December 2025 Revised 15 January 2026 Accepted 15 January 2026 Published 09 February 2026 Volume 17 - 2026 Edited by Exequiel Oscar Jesus Porta, University College London, United Kingdom Reviewed by Omobolanle Omoteso, Rhodes University Biopharmaceutical Research Institute, South Africa Mubanga Chipimo, Ministry of Health, Lusaka Zambia, Zambia Updates Copyright 2026 Zhang, Cheng and Tang

It is the most abundant molecule (endogenous antioxidant) with the lowest molecular weight, hence plays a crucial role in cellular detoxification and acts as a reducing agent

However, in many research studies, it has been found that Vitamin B12 and folic acid levels are decreased in vitiligo, which are important cofactors required for the metabolism of homocysteine

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Furthermore, low Zn concentrations are associated with alterations in the hormone metabolism (insulin and thyroid hormones) of the adipose tissue in people with obesity [68,69,70]