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We focused on ATP signaling because purinergic receptors have been found involved in crystal-evoked inflammation 24

Curcumin, while poorly absorbed in its native form, undergoes significant metabolic transformation in the liver, resulting in metabolites that are excreted in the urine and contribute to its anti-inflammatory effects

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Moreover, ILDR enhances the efficacy of ICI through microbiota- and BA-mediated mechanisms, including increased DC activation and CD8+ T cell recruitment, potentially driven by DCA enrichment ( Together, these findings suggest that targeting the microbiotaBA axis may improve the efficacy and tolerability of chemoradiotherapy