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An assessment of the role of redox cycling in mediating the toxicity of paraquat and nitrofurantoin

A brief survey of these targets follows: Cysteines that were liganded by both haloacetamide 11 and a subset of BDHI analogs include C27 of cleavage and polyadenylation specificity factor subunit 3 (CPSF3), C708 of importin-4 (IPO4), C906 of mitochondrial monofunctional C1-tetrahydrofolate synthase (MTHFD1L, also known as formyltetra-hydrofolate synthetase), and C140 of glutathione S -transferase C-terminal domain-containing protein (GSTCD)

it's about the impact they create together.

10.11842/wst.2014.05.014 18 CuiH

Laali E, Manifar S, Kazemian A et al (2020) Effect of selenium on incidence and severity of mucositis during radiotherapy in patients with head and neck cancer