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Researchers are exploring innovative strategies for neurodegenerative disorders, with EGCG emerging as a promising compound

10.1016/j.cell.2014.08.038 Cell 57 PetersonT

Chemico Biol Interact 292:7683

Thus, overactive mTORC1 inhibits mitophagy, leading to the accumulation of dysfunctional mitochondria, which contributes to increased ROS production and reduced cellular energy efficiency