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Glutathione is the most abundant antioxidant in our bodies

By directly inhibiting the activity of Gpx4 or reducing the quantity of GPX4, causes an increase in intracellular lipid peroxides, which induces a decrease in cellular antioxidant capacity and ROS accumulation, ultimately leading to the occurrence of ferroptosis (71)

Jun 2014;64(6):683-5

Minet A, Manceau A, Valada-Mennuni A, BraultFavrou M, Churlaud C, Fort J, Nguyen TM, Spitz J, Bustamante P, LacoueLabarthe T (2020) Mercury in the tissues of five cephalopods species: first data on the nervous system

Data availability The expression datasets analyzed for this study can be downloaded from the TCGA database ( The correlation between drug sensitivity and mRNA expression was analyzed using the Gene Set Cancer Analysis (GSCA) database ( The relationships between sorafenib and four ferroptosis-related genes in RCC were analyzed using the Genomics of Drug Sensitivity in Cancer (GDSC) database ( All data generated or analyzed during this study are included in this article

10.1210/edrv.22.1.0417 33 CamposH