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33 Similarly, systematic screening under ER stress conditions continues to uncover new UPR modulators that could be pharmacologically leveraged in metabolic and inflammatory pathologies

It upregulates genes for extracellular matrix proteins and growth factors and downregulates proinflammatory genes

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Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohns disease (CD), is a major and rising worldwide health concern [1]

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