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IB degradation liberates NF-B, enabling its nuclear translocation and subsequent transcription of pro-inflammatory genes (e.g., TNF-, IL-1, IL-6, iNOS) ( PPS exert multi-faceted anti-inflammatory effects by targeting key nodes in this pathway.PPS exhibit dose-dependent anti-inflammatory activity by suppressing key pro-inflammatory mediators, including TNF- (Zhu et al., 2019), IL-1 (Yang S

Systemic and topical administration work through different pathways, potentially complementing each other

They improve macrophage phagocytic activity and neutrophil bactericidal activity, resulting in better pathogen clearance from the lung

Obligate biotroph parasitism: can we link genomes to lifestyles