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The Infectious Diseases Society of America recommends amoxicillin-clavulanate rather than amoxicillin as first line treatment and doxycycline, levofloxacin, and moxifloxacin in patients allergic to penicillin.17 The emergence of bacteria resistant to current antibiotic therapies is a worldwide clinical threat

Int J Infect Dis 100:390393

Inhibition of the mTOR pathway significantly reduces the inflammatory response in microglia, highlighting how cellular metabolic pathways, particularly the mTOR-HIF-1 pathway, can influence the functional phenotype of microglia (Cheng et al., 2014)

2022;34:634648.e6

In this context, ROS-triggered TP53 activation heightens mitochondrial membrane permeability, leading to the release of pro-apoptotic factors from mitochondria

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