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Camenisch G, Stroka DM, Gassmann M, Wenger RH: Attenuation of HIF-1 DNA-binding activity limits hypoxia-inducible endothelin-1 expression

Mitochondria are vital organelles in embryos, and excessive ROS has been demonstrated to cause mitochondrial dysfunction

Ann Surg 240 : 644657

Any consideration of dose belongs completely within controlled laboratory experiments, institutional review processes, and the oversight of qualified professionals