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Encapsulation efficiency of CPT in the nanocarriers was recorded to be 87%

"Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents"

P.AlbieroM.MenegazzoL.BoscaroE.PagninE.IoriE.et al (2010)

In addition, a relative insulin deficiency stimulates gluconeogenesis in the liver and lipolysis in the adipose tissue, resulting in the release of glucose and free fatty acids, and, thereby further increasing the levels of circulating energy sources

However, despite aggressive interventions, the median survival for glioma patients is merely about 14.6 months

Gastroenterology 144 (1), 218238