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In terms of adverse effects, statins reduced stem cells osteogenic and chondrogenic differentiation potential and enhanced cell senescence and apoptosis, as shown through p16 (CDKN2A), p53 (TP53) and caspase 3, 8 and 9 upregulation

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Further mechanistic studies are needed to determine how LA regulates the MLC pathway through potentially MLCK and/or ROCK inhibition (Fig