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Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials

Toxicol Sci 57(1):615 Geiser M, Rothen-Rutishauser B, Kapp N, Schurch S, Kreyling W, Schulz H, Semmler M, Im HV, Heyder J, Gehr P (2005) Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells

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These measurements are vital for comparing solutions, setting benchmarks, and aligning with regulatory and sustainability goals

The rationale involves maintaining optimal healing capacity before injuries occur rather than responding after damage happens

Collagen remodeling is inherently slow biology