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Although PPV was considered an attractive strategy for PCa, and even after successful phase II trials, the phase III trial of 310 patients with mCRPC receiving docetaxel found no survival advantage over PBO (HR 1.04

Effect sizes vary by indication, study population, dose, and duration

AMA, American Medical Association

Winning DoD R&D Funding: SBIR, BAAs, OTAs, and the Opportunities Most Companies Miss The Department of Defense invests billions of dollars in research and development each year ($141.2B in FY2025) and a significant share of that flows directly to private industry

Excessive BDNF signaling has been associated with epileptiform activity in some research models

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