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Although hydroxyurea and 5-fluorouracil, not known to cause CIPN, did not affect neurite morphology in this model, platinum agents, taxanes, and bortezomib reduced neurite outgrowth and processes, suggesting induced pluripotent stem cell-derived neurons might be useful for the screening of potential neuroprotective drug candidates

So I hope now you can see that theres hope for your dog with Cushings

Those articles explain each compound in isolation

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Nutritional models that increase infertility risk Recently, the key nutrition model pertaining to developed and developing countries has been called the Western diet