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The most frequent cause of acquired hypothyroidism is chronic autoimmune thyroiditis, also known as Hashimotos disease

In contrast, the metabolite trimethylamine N-oxide (TMAO), GM-derived, is associated with the increased phosphorylation of tau proteins and cognitive impairment, underlining the importance of a healthy GM in preventing neuroinflammation and neurodegeneration [32,37]

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Though a detailed mechanism for release of AIM from IgM remains to be elucidated, free AIM exposes canonical SRCR binding surfaces for ligand binding and effector functions

The peptide also demonstrates significant effects on dendritic spine formation and synaptic density, contributing to enhanced cognitive function

Acknowledgments The Figures 1 5 were created with Biorender.com