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Thus, the -glutamyl cycle, apart from explaining the synthesis and degradation of glutathione, may serve as a generator of signals to activate amino acid transport into cells (75)

Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling

Second, the development of new drugs requires additional and more detailed preclinical and clinical studies to determine whether long-term use is biotoxic, whether the drug has adverse effects on other peripheral organs or whether the drug candidate has a real therapeutic effect on the patients