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Monophasic inhibition of SERCA2a activity has been reported in SR vesicles from canine, rabbit, and rat cardiac tissues at a variable concentration range ( 2+ concentration induced by LCAC superfusion ( 2+ release from the SR, regardless of RyR2-dependency, LCACs appear to alter both SR Ca 2+ uptake and release in a manner that promotes cytosolic Ca 2+ overload and can be translated to other reports of arrhythmogenic and inotropic effects of LCACs