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Identify gaps in the literature and ongoing research directions Key gaps include a lack of large, controlled clinical trials, unclear optimal dosing and delivery for reproductive targets, limited long-term safety data for systemic use, and few mechanistic human studies linking molecular changes to fertility outcomes

Gluckman, P

FEBS Lett 581:31313138 Gulyas Z, Boldizsar A, Novak A, Szalai G, Pal M, Galiba G, Kocsy G (2014) Central role of the flowering repressor ZCCT2 in the redox control of freezing tolerance and the initial development of flower primordia in wheat

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Role of -klotho in cyclophosphamide-induced ovarian injury Those individuals who have been diagnosed with POF have a notable decrease in the expression of -Klotho, which suggests a solid connection between decreased levels of -Klotho and the onset of ovarian aging (Xie et al

A lot of my patients are using [peptides], either perioperatively, around the time of surgery and more interestingly, post operatively after surgery, says Sean Alemi, MD, FACS, a double board-certified plastic surgeon and ENT