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167 By regulating mitophagy, exercise can inhibit oxidative stress, apoptosis, and inflammatory responses, offering a non-pharmacological approach to improving metabolic health

doi: 10.1152/ajpendo.00071.2001 43 TianJLuYZhangHChauCHDangHNKaufmanDL

By contrast, the inhibition of sirtuin (Sirt)3 activates the NF-B signaling pathway, leading to worsening vascular inflammation, reduced NO production, increased ROS levels and decreased levels of L-arginine, further deteriorating vascular lesions (36)