glutathione with electrophile General scheme of (GSH) conjugation to a generic disulfide reductase Metabolism

Both conditions demonstrated significant enrichment of several shared pathways, including glutathione metabolism, glutamate metabolism, folate metabolism, the Warburg effect, glucose-alanine metabolism, malate-aspartate shuttle, and arachidonic acid metabolism, indicating common metabolic perturbations associated with oxidative stress, inflammation, and mitochondrial dysfunction

TIB Molbiol, Berlin, Germany), followed by melting curve analysis

The occurrence rate of these neurological syndromes is higher in GDH-HI patients compared with patients bearing other types of CHI

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At the same time, it was agreed that symptoms affecting the central nervous system (mental function and neurological function), followed by those affecting the peripheral nervous system, are the most difficult symptoms to link to B12 deficiency (Figure 1), suggesting the need for more specific awareness in a primary medical care setting and an improvement in examination options

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