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Therapeutic targeting of ERAD and ER stress in metabolic diseases 4-Phenylbutyric Acid (4-PBA) Chemical chaperones such as 4-PBA have demonstrated beneficial effects in mouse models of obesity and diabetes, normalizing hyperglycemia and restoring systemic insulin sensitivity

Serotonin reciprocally regulates melanocortin neurons to modulate food intake

Glutathione is a substance naturally occurring in the cells of our body, the main site of synthesis being the liver

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Interestingly, ADNP mutations were found in postmortem AD olfactory bulbs and hippocampi [348]

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