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Windham, L

Methionine metabolism in the liver Methionine (Met) is an essential amino acid (AA), and nearly half of the Met consumed is metabolized in the liver in mammals

Based on the December 2025 filing, that puts a decision around OctoberDecember 2026

Biochem Pharmacol 79:10451052

38 For instance, when a plaque obstructs 7080% of a coronary vessel, shortness of breath and chest pain (angina), especially with exertion, may occur

[DOI] [PubMed] [Google Scholar] 159.Camargo C.A., Rifas-Shiman S.L., Litonjua A.A., Rich-Edwards J.W., Weiss S.T., Gold D.R., Kleinman K., Gillman M.W