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Activation of TLR ligands on astrocytes also leads to the inflammatory response in the CNS (Liddelow and Barres, 2017)

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Their pathogen-like surface architecture enhances immune recognition, although issues such as proteolytic degradation, antigen misfolding, and suboptimal presentation remain under active investigation [221, 222]

This is different from proteins that merely have a selenium as a co-factor, such as the glutathione peroxidases (the GPX family, of which GPX4 is a member), and Sec is unlike post-translationally modified amino acids such as arginine-to-citrulline or the various phosphorylations of serine, threonine, and tyrosine, among others, since Sec is incorporated directly into a growing polypeptide chain by a ribosome