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ROS has a dual role in cardiovascular physiopathology

There are two types of NOS: constitutive NOS (cNOS), which is always present in cells and produces NO when necessary, and inducible NOS (iNOS), which is not normally present but can be activated by stimuli, such as endotoxin and inflammatory cytokines

However, the endothelial damage observed in ME/CFS patients does not appear to correlate with the usual markers of endothelial dysfunction seen in cardiovascular disease such as increased levels of symmetric dimethylarginine (SDMA), asymmetric dimethylarginine (ADMA), and high-sensitivity C-reactive protein (hs-CRP), and reduced levels of arginine and homoarginine (311)

This included disabling fatigue exacerbated by exercise and associated with myalgia, excessive sleep, night sweats, irritable bowel syndrome (IBS) symptoms, and mental changes

The debilitating, slow damage created by high levels of blood sugar (glucose) destroys everything from your blood vessels to your eyes, kidneys, and nerves over time due to oxidative stress (remember the free radicals or reactive oxygen species (ROS)?)

In addition, the liposomal formulation improved the bioavailability of artesunate and dihydroartemisinin in the lungs and increased the therapeutic efficacy of drugs