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Unlike the de novo synthesis of FA, FA transport is more prominent in animal models in vivo, especially the uptake and transport of long-chain FA, which partially explains the insignificant anticancer effect of FASN inhibitors in vivo [221]

References Gautam, G

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Like taxanes, vinca alkaloids (vincristine, vinblastine) are anti-mitotic agents that target microtubules, however, these inhibit polymerization (57)

NO activates soluble guanylate cyclase [174], resulting in the generation of cGMP, which in turn activates cGKI [175]

Functionally, Vangl1 depletion mirrors E6/E7 loss in CaSki spheroids by disrupting spheroid architecture, reducing invasiveness, and increasing chemosensitivity