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Description

Abstract Glutathione-mediated biotransformation in the liver is a well-known detoxification process to eliminate small xenobiotics, but its impacts on nanoparticle retention, targeting and clearance are much less understood than liver macrophage uptake, even though both processes are involved in liver detoxification

Furthermore, the liposomes exhibited enhanced osteosarcoma targeting through estrogen functionalization, as demonstrated by the higher toxicity to MG63 osteosarcoma cells compared to the normal liver L02 cells [95]