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Finally, we explore therapeutic opportunities for targeted metabolic regulators, including traditional Chinese medicine, Sirtuin 1 activators, ATP-Citrate Lyase inhibitors, statins, folic acid, etc., providing new strategies to stabilize plaques and slow the progression of AS

Activity of VT-464, a selective CYP17 lyase inhibitor, in the LNCaP prostate cancer xenograft model [abstract 64]

Geriatr Gerontol Int 20(2):97100

To further investigate the systemic effect of low CoA on mitochondrial activity, we restricted Cse / mice to either 10% glucose or 10% galactose solution as their sole energy source in the drinking water after 6 days on control, no-Cys or no-Trp diets (Fig

Second, loss of function or mutation of Axin, GSK-3, and APC as members of the Axin complex can likewise activate the pathway and exert oncogenic effects