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Human Cytochrome P450 Enzyme Specificity for the Bioactivation of Estragole and Related Alkenylbenzenes

(18) used the experimental autoimmune encephalomyelitis (EAE) mouse model fed a KD with a high fat to carbohydrate plus protein ratio of 6.3:1, which led to increased spatial learning and memory, improved motor ability and reduced lesion size compared with EAE mice fed a standard diet

The portions of the GSTP1 surface that contribute the Cys 47 and Cys 101 residues are highlighted in yellow

At the same time, the clinical populations included in the studies typically consisted of a younger cohort, and hence, it may not be easy to generalize the findings to an older clinical cohort

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Tissue Barriers 3, e978720