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Emerging pathophysiological roles of ketone bodies

Future research might to focus on (1) optimizing formulations to improve GTC bioavailability, (2) assessing long-term health outcomes associated with GTC consumption, (3) rigorously evaluating safety and potential side effects at higher doses, as well as therapeutic efficacy in specific diseases and stages, and (4) investigating gut microbiome interactions, given their influence on GTC metabolism and effectiveness

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Johns Wort (300 mg three times daily for 14 days) significantly decreased the systemic exposure of omeprazole in CYP2C19 poor metabolizers (Cmax and AUC both decreased by 38%) and extensive metabolizers (Cmax and AUC decreased by 50% and 44%, respectively) [see Drug Interactions (7)]

Oral supplementation with glutamine (1 g/kg) plus L-alanine (0.61 g/kg) or 1.49 g/kg L-alanyl-L-glutamine dipeptide was able to attenuate total NF-kB p65 expression in mouse gastrocnemius skeletal muscle after LPS stimulation in an animal sepsis model promoting anti-inflammatory effects via the NF-kB pathway [86]

A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain