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Drug synergism was measured using the Loewe model with Combenefit software (Cancer Research UK Cambridge Institute), and the combination index was calculated using CompuSyn software (ComboSyn) ( 3 Results 3.1 CB-839 treatment inhibits glutathione synthesis and the conversion of glutamine to glutamate in CLL cell lines Initially, we investigated CB-839s functional inhibition of GLS-1 ( Figures 1A, B )

Suppressed oxidative distress in those cases may have a negative impact on health

doi: 10.1089/thy.2008.0056 66

Prcaution : Ne pas dpasser la portion journalire recommande

For glutathionylation experiments, 30 10 6 cells were washed with RPMI supplemented with 0.5% FBS and 100 U/mL penicillin-streptomycin and resuspended in a total volume of 5 mL of the same medium

Association not cause It is also worth bearing in mind that observational studies, such as this, dont provide proof of causation