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While advances in bioinformatics and nanoformulations are enhancing their pharmacokinetic profiles and clinical applicability, challenges such as standardization, dosage optimization, and translational validation hinder their widespread clinical adoption

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These agents downregulate intracellular TYR protein levels by promoting ubiquitin-dependent degradation, inhibiting melanin synthesis and suppressing hyperpigmentation

Although these studies did not investigate the effects of urolithin A on sleep directly, they have shown that urolithin A may help mitigate the adverse effects of sleep deprivation, with potential to improve daytime function and perceived well-being in individuals with poor sleep health

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