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By thoroughly understanding resistance mechanisms, clinicians can develop more precise treatment plans based on patients specific molecular characteristics, thereby significantly improving treatment outcomes

doi: 10.1161/01.STR.0000217418.29609.22 14 BanksW

doi: 10.1124/jpet.117.244376 104

Pharmacol Res 2020;152:104615.ArticlePubMed 18

Community oral doses (50-150 mg daily) are based on allometric scaling from mouse studies, oral bioavailability data, and several years of community trial and error