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Platelet Anti-Aggregant Activity and Bioactive Compounds of Ultrasound-Assisted Extracts from Whole and Seedless Tomato Pomace

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Insulin normally suppresses gluconeogenesis while promoting lipogenesis, however, under insulin resistant states such as T2D, hepatic lipogenesis remains insulin sensitive and suppression of gluconeogenesis is insulin resistant, leading to a metabolic state called selective hepatic insulin resistance (199)

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They can also cause side effects like dizziness, stomach upset, or feeling very tired, which makes some patients stop using them