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Resman et al., 2012) to 19-74% in 2016-2021 (Wang et al., 2019

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[0252] The human antibody can have at least one or more amino acids replaced with an amino acid residue, e.g., an activity enhancing amino acid residue which is not encoded by the human germline immunoglobulin sequence

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Beam plans to begin a clinical trial using an alternative to chemotherapy by the end of 2025, with the goal of improving safety for patients