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A decrease in serum levels of IL-1a, IL-6, IL-10, IL-12p70, and TNF was reported, but placebo caused a significantly greater decline in the production of IL-6, IL-12p70, and TNF, as well as IL-15, IL-17

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doi: 10.1016/j.biotechadv.2011.12.004

Furthermore, our own studies have shown that pharmacological targeting of NK-1R with the antagonist L703,606 can not only prevent the development of damaging inflammation due to streptococcal CNS infection when administered prophylactically, but can also reverse infection-associated gliosis and demyelination when delivered therapeutically without increasing CNS bacterial burden (Chauhan et al., 2011)

Even though we confirmed that astrocyte activation induces lactate release in the extracellular space, we cannot exclude that other mechanisms might be activated by optogenetic stimulation of astrocytes