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Description

Many investigational agents have targeted mitochondrial function, including TUDCA [8, 149]

ER Ca 2+ release, sustained store-operated Ca 2+ entry, and persistent cytosolic Ca 2+ elevation can continue to damage PACs even when mitochondrial Ca 2+ entry through MCU is reduced, because calcium-dependent digestive enzyme activation, PM injury, and failure of ATP-dependent ion pumps remain operative

Glutathione improves skin health and slows down ageing by reducing oxidative stress

Kocsy et al., 1996

We believe that these are through local iron overload (Toyokuni, 2013b)

Then, the resulting data matrixes were imported into SIMCA 14.0 software (Umetrics, Sweden) for multivariate data analysis, including principal component analysis (PCA) and orthogonal partial least square discriminant analysis (OPLS-DA)