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10.1096/fj.02-0078fje 63

Key Points Glutathione serves as a crucial endogenous antioxidant that plays a pivotal role in combating oxidative stress associated with dementia NAD is essential for energy metabolism and mitochondrial function, with potential implications in neurodegenerative diseases like dementia NAC acts as a precursor to glutathione synthesis and exhibits antioxidant and anti-inflammatory activities beneficial for neurodegenerative conditions IV Glutathione Studies suggest that elevating glutathione levels through IV administration may offer a therapeutic strategy to combat oxidative stress in Alzheimer's disease and mild cognitive impairment Glutathione's antioxidant properties play a significant role in protecting neurons from oxidative damage, potentially slowing disease progression IV NAD NAD levels decline with age and have been implicated in neurodegenerative diseases like dementia

As described above, the lack of GSH, although without effect on re-oxidation of roGFP2 in the periplasm, slightly shifted the periplasmic redox homeostasis to more reducing conditions, as seen in the lowered redox potential of roGFP-iL in those cells (Fig

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