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writingreview and editing, M.F., J.C., C.C

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41 ParkY.SmithR

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Lancet (2014) 383(9932):193343

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under normal conditions, BDNF binds to TrkB receptors to activate pathways such as ERK and Akt, activating the mammalian target of rapamycin complex 1 (mTORC1), which drives synaptic protein synthesis, promoting dendritic spine and synapse formation, and maintaining synaptic structures (118)

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Animal models reveal a better understanding of the antidepressant mechanism of neuromodulatory techniques such as deep brain stimulation (DBS), which is observed to work through activating brain derived neurotrophic factor (BDNF) related pathways

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Dihexa is a remarkable peptide originally developed to combat neurodegenerative diseases

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