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In murine studies, deletion of the IGF-1R in skeletal muscle resulted in glucose intolerance issues ultimately leading to T2D at an early age, because, although they express insulin receptors, they cannot form hybrid or IGF-1 receptors [162]

doi:10.1007/s12603-010-0330-4

The combination remains speculative but represents logical stacking based on mechanism understanding

Wearing scarves, and using a heating pad on your neck/shoulders to allow for continued blood flow to your head is ideal