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In biochemical and cellular research systems, Sermorelin interacts with the growth hormonereleasing hormone receptor (GHRH-R) expressed on pituitary somatotroph cells, initiating intracellular signalling cascades that regulate growth hormone synthesis and release

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It has been shown that 7-month-old Tg4-42 animals display a neuron loss of more than 50% in the CA1 region of the hippocampus as well as a 28% neuron loss in the CA2/3 region and 14% loss in the dentate gyrus 19,20

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