is selenium is part of the glutathione peroxidase enzyme system Rational redesign active site of selenosubtilisin with strongly enhanced activity Selenoneine-inspired selenohydantoins with glutathione peroxidase-like

Fibroblasts were seeded in a 96-well imaging plates (CELLSTAR black CLEAR, Greiner Bio-One) at a density of 3 10 3 cells per well and cultured for 24 h at 37 C in a 5% CO 2 incubator in complete high glucose DMEM supplemented with 20% FBS

Neuronal GPX4 is downregulated after SCI, and ferroptosis inhibitors SRS 16-86 and DFO both prevent the reduction of GPX4 and improve the survival rate of neurons in the injured spinal cord to repair SCI-associated motor dysfunction

To this end, researchers have developed or screened a range of drugs and compounds capable of inhibiting ferroptosis through various approaches and have validated their neuroprotective effects using various disease models (Table III)

Mitochondrial outer membrane protein FUNDC2 promotes ferroptosis and contributes to doxorubicin-induced cardiomyopathy

Bull Exp Biol Med 177:751756

KO contains both PLs and triglycerides (TAG), and the content of PLs is as high as 65% (59)