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It primarily consists of CD4+ lymphocytes, specifically Th2 cells, although Th1 cells and Th17 cell-derived cytokines are also found at increased levels in the blood (117)

[DOI] [PubMed] [Google Scholar] 362.Jin Z, Dridi N, Palui G, Palomo V, Jokerst JV, Dawson PE, Amy Sang Q-X and Mattoussi H, J

The resulting catastrophic energy deficit is a primary physiological driver of post-exertional malaise (PEM) or 'crashes,' where even minor, everyday activities trigger a disproportionate and prolonged exacerbation of profound fatigue, muscle weakness, and cognitive impairment

A.GentryC.LightE.VastaniN.VallortigaraJ.BierhausA.et al

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doi: 10.2967/jnumed.120.244400 125 HardyJ.SelkoeD