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Wang Y, Shan Y, Wang Y, Fang Y, Huang T, Wang S, Zhu Q, Li X, Ge RS (2019) Aconitine inhibits androgen synthesis enzymes by rat immature Leydig cells via down-regulating androgen synthetic enzyme expression in vitro

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Biochanin a ameliorates DSS-induced ulcerative colitis by improving colonic barrier function and protects against the development of spontaneous colitis in the Muc2 deficient mice

For example, the compound 13 (racemic) is a very week IRAP inhibitor (Lukaszuk et al., 2011) and compound 14 with a 4-hydroxydiphenylmethane scaffold as a substitute for Tyr 2 is essentially inactive (Figure 4) (Andersson et al., 2008)

For an avascular structure like a disc, even modest improvements in surrounding blood flow could meaningfully increase nutrient delivery

To view or add a comment, sign in The DDI Profiling Panel is essential for evaluating how a new drug interacts with existing therapies, potentially impacting metabolism and efficacy