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Additional neurotrophic factors, including insulin-like growth factor 1 (IGF-1) and nerve growth factor (NGF), exert complementary effects by regulating cellular metabolism, promoting anti-apoptotic pathways, and enhancing myelination [239, 240]

Serum opioid peptide concentration was 1.6-fold significantly higher in children with ASD ( p : Rueda-Ruzafa L, Cruz F, Cardona D, Hone AJ, Molina-Torres G, Snchez-Labraca N, Roman P (2020) Opioid system influences gut-brain axis: dysbiosis and related alterations

and (c) R-PE

(2021) Homocysteine and folic acid: Risk factors for Alzheimers disease- An updated meta-analysis, Frontiers in aging neuroscience, [online] Available at: (accessed 7th April 2022) Xiao, Y., Zhang, Y., Wang, M., Li, X., Xia, M

When sorafenib (25 nM) combined with arsenic trioxide (1 M), a synergistic apoptosis inducing effect was observed in FLT3-ITD MOLM13 AML cells, which is related to the inactivation of FLT3-ITD (both expression and phosphorylation) and GSK3, the upregulation of Bax and Bak and the downregulation of Mcl-1

J Neuroendocrinol (2021) 33(4):e12932